Telomere Protection: An Act of God
نویسندگان
چکیده
Telomeres are nucleoprotein structures that shelter the ends of linear chromosomes from being inappropriately recognized as DNA double-strand breaks. New work has revealed that Apollo, a nuclease previously implicated in DNA repair, also has a role in safeguarding telomeres during S phase.
منابع مشابه
Epigenetic Telomere Protection by Drosophila DNA Damage Response Pathways
Analysis of terminal deletion chromosomes indicates that a sequence-independent mechanism regulates protection of Drosophila telomeres. Mutations in Drosophila DNA damage response genes such as atm/tefu, mre11, or rad50 disrupt telomere protection and localization of the telomere-associated proteins HP1 and HOAP, suggesting that recognition of chromosome ends contributes to telomere protection....
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Objective: Disable people need special legal attention. In this regard, special rules have been gradually developed by domestic and international law. Convention for the Protection of the Disabled Disability (2006) in the international community and the Iranian Act of comprehensive protection of the disable people (1383) in a national community are examples of above mentioned legal develop...
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Telomeres are repetitive sequences at the natural ends of linear eukaryotic chromosomes that protect these from recognition as chromosome breaks. Their ability to do so critically depends on the binding of sufficient quantities of functional shelterin, a six-unit protein complex with specific and crucial roles in telomere maintenance and function. Insufficient telomere length, leading to insuff...
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عنوان ژورنال:
- Current Biology
دوره 16 شماره
صفحات -
تاریخ انتشار 2006